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Although ED can be caused by various conditions, about 7 in 10 cases are due to narrowing of the small arteries in the penis. This causes reduced blood flow to the penis. This is the same problem that can occur in other blood vessels. For example, narrowing of the blood vessels in the heart (the coronary arteries) is a cause of angina and other heart problems. Narrowing of blood vessels to the brain is a risk factor for having a stroke. Narrowing of blood vessels in the legs can cause peripheral arterial disease. non prescription levitra have pulmonary hypertension

The information contained on this web site is for your information only. You should never take a drug without a doctor's prescription. Do NOT give yourself any drug unless it has been prescribed for you by a doctor.For Erectile Dysfunction "I'm in my early 50's, I decided to give this a try, fatigue and age catching up with me, half hard most of the time. I took 50mg. and waited a couple hours, went to bed with the wife. Wow is all I can say! Twice! We have enjoyed it every since. Pricey though."Pharmaceutical Form 25mg, 50mg, 100mg tablets 2.5mg, 5mg, 10mg, 20mg tablets 5mg, 10mg, 20mg tablets

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In vitro studies have shown that the effect of tadalafil is more potent on PDE5 than on other phosphodiesterases. These studies have shown that tadalafil is >10,000-fold more potent for PDE5 than for PDE1, PDE2, PDE4, and PDE7 enzymes, which are found in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle, and other organs. Tadalafil is >10,000-fold more potent for PDE5 than for PDE3, an enzyme found in the heart and blood vessels. Additionally, tadalafil is 700-fold more potent for PDE5 than for PDE6, which is found in the retina and is responsible for phototransduction. Tadalafil is >9,000-fold more potent for PDE5 than for PDE8, PDE9, and PDE10. Tadalafil is 14-fold more potent for PDE5 than for PDE11A1 and 40-fold more potent for PDE5 than for PDE11A4, two of the four known forms of PDE11. PDE11 is an enzyme found in human prostate, testes, skeletal muscle and in other tissues (e.g., adrenal cortex). In vitro, tadalafil inhibits human recombinant PDE11A1 and, to a lesser degree, PDE11A4 activities at concentrations within the therapeutic range. The physiological role and clinical consequence of PDE11 inhibition in humans have not been defined. how much does cialis cost without insurance Congenital or Acquired QT Prolongation


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